![]() 1.3 Retargeting of Bio-Nanocapsuleīin Fei, Yang Ming, in Reference Module in Materials Science and Materials Engineering, 2021 In summary These results show that BNC has great potential as a gene delivery system targeting liver cells and tissues. In addition, although adenovirus vector is used in ordinary gene treatment and excluded by immunity in a few days, a few weeks of successive expression was confirmed in the administration of BNC. This was a promising expressed level that is expected to show a therapeutic effect in patients with advanced hemophilia B. Consequently, by administering BNC containing FIX expression gene only once to the tail vein intravenously, expression of FIX was detected in the blood of the mouse. Therefore, as a model of gene therapy, an experiment to verify the treatment of hemophilia B with blood clotting factor IX, FIX expression gene was conducted. Expression of GFP was not observed in other tissues. In a tumor-bearing mouse that had been implanted human hepatoma–deprived cell line, GFP expression vector was delivered only in human hepatoma–derived solid cancer. However, expression of GFP was not observed in the non–hepatoma cell line. BNC encapsulated with GFP-expressed gene was added to the human normal liver cell and human hepatoma–deprived cell line by electroporation as described in the previous section, and fluorescence expressed by GFP was observed. Gene delivery by BNC was conduced by BNC with the expression vector for Aequorea coerulescens–derived green fluorescence protein (GFP). ![]() Therefore, with low-molecular compounds, BNC has great potential for drug delivery specific to the human liver cells and tissues. Kupffer cells in the liver usually phagocytize xenobiotics however, BNC was not recognized as a xenobiotic. Fluorescence was observed in the implanted human hepatoma–derived tumor tissue but not in internal organs or human colon cancer–derived tumor tissue in the mouse. Human hepatoma–derived cell line (NuE) and human colon cancer–derived cell line (WiDr) were implanted subcutaneously in the back of nude mice, and BNC, including calcein, was administrated intravenously from the tail vein. Pinpoint delivery of bio-nanocapsule encapsulated with calcein to the human liver cell. The nanocapsules notably diminished the movement of oxybenzone through porcine ear skin. 192 In this case, the nanocapsules were not as efficient in delivering OMC the encapsulation of benzophenone-3 in some NPs containing PVA-fatty acid were more effective. OMC was simultaneously encapsulated in cellulose acetate phthalate nanocapsules and its penetration in the SC was compared to that from a nanoemulsion. Polymer PCL was used to prepare OMC-loaded nanocapsules for efficient shielding to UVB radiation. They generated a preservative layer on the skin surface and retarded the permeation of the actives in sunscreen to the viable layer. 10 Nanocapsules were examined as sunscreen carriers for octyl methoxycinnamate (OMC), octyl salicylate, and benzophenone-3. ![]() 192Īpplication of nanocapsules has reduced the penetration of UV filter octyl methoxycinnamate in skin over customary mixtures. ![]() 10 L'Oréal marketed Primordiale Intense and Hydra Zen Serum using nanocapsules to encapsulate various active ingredients. One of the earliest nanocapsule-based products in the market was an antiwrinkle lotion with vitamin A nanocapsules that gradually discharge the active through time. Nanocapsules are employed in cosmetics to protect sensitive actives, decrease unwanted odors, and remove incompatibility between formulation components. Nanocapsules, submicroscopic tiny bits, are polymeric capsules surrounded by a watery or oily core. Maibach, in Cosmetic Science and Technology, 2017 22.4.3.1 Nanocapsules ![]()
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